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HYGIENE A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS A61P17/00Drugs for dermatological disorders AHUMAN NECESSITIES A61MEDICAL OR VETERINARY SCIENCE

ERR agonism the primary driver ERR is highly expressed in energy-demanding tissues such as skeletal muscle, heart, brown adipose tissue, and liver

Further, the NADH from increased glycolysis in the cytosol can be transferred to mitochondria to drive NADH-dependent NNT

248 Also, SAM has a key role in regulating liver homeostasis, and reduced levels of SAM synthesis have been detected in various chronic liver injuries, such as NAFLD